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Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells via the PI3K/AKT/mTOR pathway
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A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
For instance, oppositely charged drug molecules and polyelectrolytes can form complexes that significantly improve solubility

Silencing ACSL4 in the substantia nigra can prevent dopaminergic neuron death and motor defects in PD mice, and inhibition of ACSL4 activity with triacsin C can improve the PD phenotype