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Mild side effects and potential risks, which should be referred to a doctor if they persist or worsen, include: pain, redness, or itching at the site of the injection mild diarrhea swelling sensation in the body More serious side effects, which require immediate medical attention, include: muscle cramps irregular heartbeat unusual weakness or tiredness swelling of the ankles or feet Severe reactions are very rare but require emergency intervention

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If you prefer evening supplementation and experience no sleep disturbances, there is no medical reason to change your routine

Managing the Awakening Response For those with severe tendonitis, the morning cortisol spike can be a double-edged sword

Cook N, 2023, 'A phase 1/2 study of dendrimer-enhanced (DEP) SN38 (SN38-SPL9111/DEP irinotecan) in patients with advanced solid tumours', MOLECULAR CANCER THERAPEUTICS , 22, Journal articles | 2023 O'day R

A 2 mg target dose is 2,000 mcg