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The results showed significantly upregulated mRNA levels of various reproductive related markers e.g., VASA, STELLA, mothers against decapentaplegic homolog 1 (SMAD1), DAZL and the expression of spermatogenic related proteins e.g., germ cell nuclear factor (GCNF), heat shock protein 90 alpha (HSP90), integrin 1, and C-KIT, without any adverse reactions

When IDO-1 is activated, it negatively impacts cellular energy metabolism by catalyzing the conversion of tryptophan into kynurenine, leading to tryptophan depletion

J.NewtonM

PMID: 34638306

Nat Commun 15 , 2007 (2024)

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