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During this era, companies aimed to identify MC4R-specific agonists

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Vignarajah D

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& OMalley, B

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Urdinguio, R

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A further limitation, which has been widely acknowledged (Yamada et al., 2000), is that exogenous LCAC effects are more correctly estimated by determining the LCAC to protein or membrane mole ratios instead of utilizing absolute LCAC concentrations

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For example, a receptor protein will need to have the signal-binding site on the exterior surface of the membrane where the signaling molecule is present

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