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In these studies, small intestine gene expression of ZO-1 and occludin were reduced in mice fed a high-fat diet and distribution altered in ob/ob mice

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Butcher EC, Berg EL, Kunkel EJ (2004) Systems biology in drug discovery

On examination, she was afebrile, conscious, alert and oriented, noted to have pallor, bipedal oedema, hyperpigmentation over the tongue, bilateral hands and feet (Fig

The main causes are eating habits, alcohol consumption, and metabolic disorders

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