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Pathologic angiogenesis is implicated in the proliferation of tumor cells, as well as in immune and inflammatory disease processes [68, 69]

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Such direct effect can ascertain channel functioning in disturbed electrolyte circumstances (i.e., hyperkalemic [83] and hypokalemic [84] or hypermagnesemic [85] condition) and counteraction of channel disturbances that were induced using the agents that otherwise block channel function

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