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The initiation of RA by inflammation characterized by an aberrant Th-17-dominated immune response, neutrophil activation, antigen citrullination, and anti-cyclic citrullinated peptide (CCP) production is exacerbated by microbial dysbiosis, the presence of oral pathobionts (e.g., Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans ), and periodontitis has been described (165167)

Wang T, Dong Y, Huang Z, Zhang G, Zhao Y, Yao H, et al

Remuzzi, G

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Co-administration produces synergistic GH release the combined output exceeds the mathematical sum of either peptide administered alone

SEM and Fourier transform infrared spectroscopy (FTIR) confirmed that bentonites are effective OTA binders