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In one study, treatment with honokiol reduced pain-related behaviors in mice in experimental models of inflammation (Lin 2009)

MillmanJFOkamotoSTeruyaTUemaTIkematsuSShimabukuroMet al

Increased prevalence of depression in cohorts of the elderly: an 11-year follow-up in the general population the HUNT study

2932 Edecesertib, another IRAK4 inhibitor, is being developed for cutaneous lupus erythematosus and rheumatoid arthritis and is well-tolerated and non-toxic

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Therefore, more randomized controlled trials are required in this regard