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10.1016/j.metabol.2015.09.004 42
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In contrast to the majority of anti-diabetic compounds, DPP-4 inhibitors do not produce weight gain as a side effect, which is crucial for limiting body weight gain during long-term therapy for diabetes
Concurrently, advances in genetics and functional genomics have strengthened causal inference by linking peptide pathways to human phenotypes through loss-of-function variants, expression quantitative trait loci, and Mendelian randomization studies
doi: 10.1016/j.metabol.2015.02.001
For the future of metabolic therapeutics, survodutide's Phase 2 data are encouraging, particularly for MASH where the glucagon mechanism provides a uniquely differentiated approach
