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2 Pathogenesis of DCM DCM is usually characterized as a contractile dysfunction with later onset of HF without association to dyslipidemia, hypertension or coronary artery disease, but instead caused by metabolic and humoral disruption in connection with hyperglycemia, hyperinsulinemia and insulin resistance ( The two main factors that drive DCM are long-term hyperglycemia and insulin resistance

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[DOI] [PMC free article] [PubMed] [Google Scholar] 184.He X, Pei Q, Xu T and Zhang X, Sens

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When combined with nanoencapsulation, such digital twins could be used to test how different carrier designs, doses and dosing schedules affect simulated post-prandial responses, nutrient status or inflammatory markers before any intervention is implemented in vivo (255)

Peptide stability is temperature-sensitive, pH-sensitive, and shear-sensitive