glutathione dependent transporter transporters. Plasma membrane GSH efflux pumps . Two GSH Functional and Structural Diversity of

Pulmonary function measurements Pulmonary function was assessed using WBP (TOW-INT, China) before euthanizing the mice

In a short, aerobic exercise benefits to cardiorespiratory function and blood circulation, boosting oxygen and nutrient delivery to tissues and enhancing antioxidant defenses

These two GLS-derived isoforms are often referred to as glutaminase C (GAC) and kidney-type glutaminase (KGA) but are collectively the glutaminase 1 (GLS1) enzymes

Chemicals and antibodies The commercial sources of chemical reagents were as follows: TBH (75-91-2, Sigma-Aldrich), RSL3 (19288, Cayman), SirReal2 (S7845, Selleck), Ferrostatin 1 (ab146169, Abcam), Z-VAD-FMK (S7023, Selleck), Necrostatin-1 (S8037, Selleck), Succinyl-CoA (S1129, Sigma-Aldrich), Nicotinamide (98-92-0, Sigma-Aldrich), Vorinostat (SC0231, Beyotime), NAD+ (S2518, Sellect), C11 BODIPY 581/591 (27086, Cayman), BSO (B2515, Sigma-Aldrich), SGC-CBP30 (S7256, Sellect), Fasnall (F413416, Aladdin)

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Incorporating analogous mitochondria directed GSH-sensing reporters into nanoplatforms would allow simultaneous readout and modulation of intramitochondrial redox status, enabling closed-loop theranostic schemes i.e