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Patients with major depressive disorder showed decreased amplitudes and delayed/advanced phases of the circadian rhythms such as core body temperature and melatonin [58,59,60]

Transcriptional responses of the vasopressin and corticotropin-releasing hormone genes to acute and repeated intraperitoneal hypertonic saline injection in rats

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Common causes include weak digestion, inflamed intestines, bacterial infections, microbiome imbalance, nutrient deficiencies, food allergies (especially gluten and dairy), chronic stress, overtraining, high estrogen levels, mold exposure, and genetic variations in DAO and HNMT genes

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