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As a selective substrate site-targeting inhibitor of nicotinamide N-methyltransferase (NNMT) the cytosolic enzyme responsible for the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor 5-Amino-1MQ is studied as a tool compound for investigating NNMT enzyme activity, NAD salvage pathway interactions, and methylation pathway dynamics in controlled in-vitro experimental systems

doi: 10.1186/1477-7819-5-128

End of follow-up of infants (for collecting primary outcomes) will be completed approximately 18 months after the last enrolment

Interestingly, adipocyte deletion of HSL causes FLD by 8 months of age, while hepatocyte KO of HSL does not (150)

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