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doi: 10.1371/journal.pone.0055774

J Exp Biol 224:jeb221606 Zhang R, Al-Lamki R, Bai L, Streb JW, Miano JM, Bradley J, Min W (2004) Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner

This decrease is associated with increased expression of uncoupling proteins and a loss of inner membrane potential, leading to impaired ATP synthesis

Kantarjian H, O'Brien S, Jabbour E, Garcia-Manero G, Quintas-Cardama A, Shan J, Rios MB, Ravandi F, Faderl S, Kadia T, Borthakur G , Huang X, Champlin R, Talpaz M, Cortes J

doi: 10.1016/S2213-8587(21)00089-9 53 Geva-ZatorskyN.SefikE.KuaL.PasmanL.TanT

Finally, it is important to note that hotspot TP53 missense mutations might have a distinct impact on the pathophysiology of cancer cells from that of truncating mutations or homozygous deletions which lead to absence of functional protein 59,61 , underscoring an additional layer of nuance when considering the role of tumor suppressor genes in PDAC