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proposed a mode of enhanced ferroptosis activation through modulation of tumor cell glucose metabolism by utilizing TA coordinated with V oxides and loaded with lonidamine (LND)

Acknowledgments The authors would like to thank the patients for their participation in this study and permission to publish

Peripheral cytokines reach the brain through different non-exclusive mechanisms, including bloodbrain barrier (BBB) disruption 62 , penetration of peripheral immune cells, and via afferent nerve fibers, such as the vagus nerve, a bundle of parasympathetic sensory fibers that conveys information from peripheral organs to the CNS 63

30 In this case, the signal generated by the presence of radicals stimulates the production and transportation of specific antioxidants to the site of damage