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During oxidative folding, an oxidized PDI donates a disulfide to a substrate cysteine, becoming reduced in the process

Therefore, endogenous anti-oxidative systems play an important role in cell survival under physiological and pathological conditions

[ 179 ] BACH1 is active in the TGM2 + macrophage subtype, which promotes macrophage antiinflammatory responses in pancreatic ductal adenocarcinoma (PDAC)

biologic agents targeting tumor necrosis factor (TNF), integrins, and interleukins

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