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The lack of FDA approval for cosmetic use reflects insufficient clinical evidence demonstrating safety and efficacy for skin lightening purposes

Interestingly, most of the antigens that have been extensively assessed, such as cruzipain, trans-sialidase, and non-specific B-cell mitogens, marked in bold in Figure 1 and described in Supplementary Table II, participate in pathways involved in the manipulation of the host immune system

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Statements Author contributions KoH: Data curation, Writing original draft, Writing review and editing

Focus on Mammalian Thioredoxin ReductasesImportant Selenoproteins With Versatile Functions

Int J Pharm Pharm Sci 8(3):352355 Poddar S, Sarkar T, Choudhury S, Chatterjee S, Ghosh P (2020) Indian traditional medicinal plants: a concise review