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Aged mouse cortical microglia display an activation profile suggesting immunotolerogenic functions

For example, the reduction of pyruvate to lactate, as catalyzed by lactate dehydrogenase, is accompanied by the oxidation of NADH to NAD + , as shown in the following two half-reactions: To evaluate the driving force for the full reaction to occur, one would consider the standard reduction potential, E, associated with each of the individual half reactions