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Delphi Survey Rounds The questions that received consensus in the first survey (Table S4) were revised and used in the second survey (Table S5)

IGF-1 availability is tightly regulated by the so-called insulin-like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF-1R) [9395]

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A natural decline occurs over time in the levels of collagen, with production of new collagen decreasing and existing collagen reducing structural and functional integrity

Researchers assessing the blend sometimes reference such ranges when planning experimental protocols for controlled in-vitro testing and preclinical investigation, but interpretation requires careful consideration of the specific research context and methodology