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Furthermore, manganese is involved in the production of specific antioxidants within pulmonary tissue, such as Mn-SOD located within mitochondria [69]

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Roers, A., Hiller, B

however, studies on fibroblasts, induced neurons and astrocytes derived from PKAN patients have highlighted the main role of mitochondria in triggering pathological events [144,145,146,147,148]

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Still, further studies are needed before routine use is advised