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A single FOXO4-DRI dose clears accessible senescent cells within the circulation and tissues with high vascular permeability, but deeper tissue reservoirs require time for macrophage-mediated clearance of apoptotic material before a second dose can access previously shielded senescent populations

Furthermore, insulin-sensitizing agents, which are classic treatments for improving glycemic control, have shown promise in enhancing cognition

Allen, Lymaris Enriquez, and Breanna Surace of Dr

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The fact that it is not degraded in human gastric juice for more than 24 h demonstrates the effectiveness of a therapeutic per oral regimen (for a review, see [18])