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Mitochondrial structural and functional changes are reported to involve in aging, cancer, metabolic syndromes, including stroke, ischemia, pre-diabetes, diabetes, obesity, hypertension, dyslipidemia, heart disease, alcohol injury, and neurodegenerative diseases

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Similar to CAF (Canas et al

This observation implies that the selenoprotein GPx4 holds promise as a novel therapeutic target for the treatment of lung cancer (73, 74)

[DOI] [PubMed] [Google Scholar] 54.Holmay M.J., Terpstra M., Coles L.D., Mishra U., Ahlskog M., Oz G., Cloyd J.C., Tuite P.J

Dysfunction of the ETC, such as deficiencies in Complex III or V, leads to fatty acid accumulation and reduced histone acetylation levels, ultimately impeding hepatocyte proliferation [151]