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The mode of NOX-2 inhibition seems to stem from an inhibition of platelet-derived growth factor (PDGF)-mediated NAD(P)oxidase activation (Ten Freyhaus et al., 2006)
7.5 Saponins: guardians of mitochondrial integrity and lipid peroxidation Saponins protect against ALD by inhibiting CYP2E1 to reduce ROS generation during ethanol metabolism, while PPAR- activation promotes fatty acid -oxidation and HDL synthesis (Yang et al., 2021a
