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SAM is the universal methyl donor for DNA methylation

Accumulation of A in the AD brain induces an endoplasmic reticulum stress response that decreases GSH levels and leads to increased ROS [97]

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doi: 10.1089/ars.2018.7626 [DOI] [PMC free article] [PubMed] [Google Scholar] 337

This indicates that the treatment with exogenous ITC might have a negative feedback on GSL biosynthesis, although the effect on GSL levels would not be expected to be seen after such a short exposure time

Although some transamination of cyst(e)ine to 3-mercaptopyruvate appears to occur in vivo based on the observed excretion of mercaptolactate in the urine of patients with 3-mercaptopyruvate sulfurtransferase deficiency (Crawhall et al