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doi: 10.1172/jci.insight.133929 46 WasHDulakJJozkowiczA
Normally, NAPQI is rapidly de-toxified by conjugation with glutathione, but the pathway can become saturated as a result of overdose, combination with alcohol, or in individuals with polymorphisms in the P450 metabolizing enzymes
The superoxide radical can be further converted to H2O2 by the enzyme SOD [44]
