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Structural distinction drives function : NADP contains one extra phosphate group compared to NAD, directing it toward anabolic reactions while NAD handles catabolic energy production

2c and Table 1), which is similar to that of the complex between 5 and VpreB U (3.0 nM), supporting the idea that mainly the VpreB-UR causes the decreased affinity

Nutrients 13:3304 Olson GE, Winfrey VP, Hill KE, Burk RF (2008) Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells

Excessive NAM depletion directly reduces the substrate supply for NAD+ synthesis, leading to decreased intracellular NAD+ levels

doi: 10.3389/fmicb.2022.889472 82 KoopD