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5,10-Methylene tetrahydrofolate (THF) is required for the synthesis of nucleic acids and is reduced to 5-methyl THF by methylene THF reductase, a flavin-dependent enzyme that uses NADPH as a cofactor

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Hold GL, Smith M, Grange C, Watt ER, El-Omar EM, Mukhopadhya I

Rather than directly activating GABA-A receptors, the peptide appears to maintain homeostasis of the entire GABA receptor complex, preventing the desensitization and compensatory changes that produce tolerance and dependence

Description of the procedure, and its application to diagnosis of patients with organic acidurias