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Short Chain Fatty Acids Gut bacteria produce SCFA metabolites that can regulate motility, secretion, and gut-brain signaling by acting through FFARs on epithelial cells, EECs, ECCs, immune cells, and intrinsic and extrinsic neurons 12, 91 (Figure 2) 119

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Reigstad CS, Salmonson CE, Rainey JF et al (2015) Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells