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Orthostatic Venous Hypertension In the upright position and in the absence of muscle contraction, venous hydrostatic pressure measured on the dorsum of the foot ranges from 90 to 120 mmHg, depending on the individual's height [6]

Szymczak-Pajor et al, 2022)

We're throwing all that potential data away that could be used to actually identify real safety and evidence signals

the dosage is preferable in the range from 10 -5 to 10 -2 mg/kg of body weight, applied systemically or topically in higher concentration between 0.1% to 0.5%

All current findings remain pre-clinical and exploratory , with ongoing research aimed at better understanding 5-Amino-1MQs role as a research tool for metabolic and enzymatic signaling analysis