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Add peptides providing complementary mechanisms

G., Maffei Facino R

2016;8:330ra337

The peptide has a uniquely high affinity for copper ions, forming a stable chelate with copper(II) that is more exchangeable than the copper bound to albumin, allowing efficient copper delivery to tissues

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD