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Nat Commun 8:11771177 Kimura H (2002) Hydrogen sulfide as a neuromodulator

Since the measurement of 2,3 DPG is technically difficult and because of the excellent correlation between red cell levels of 2,3 DPG and creatine, the red cell creatine measurement represents a simpler clinical assay for evaluating tissue hypoxia as a manifestation of both cardiopulmonary insufficiency and decreased circulating red cell mass

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Circulation 2004;110:955961