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Maria Nuzzaci contributed to manuscript preparation and revised the manuscript

Our observation is also supported by the recently published metabolome atlas of the aging mouse brain (N = 10 ROIs, four age groups) that demonstrates region-specific variations in glutathione levels when investigating (a) single time-points, as well as (b) age-specific changes (Ding et al., 2021)

Lynda Scammell, the head of borderline products at the MHRA, said: Where medicinal claims are made, or products are being used in a way which brings them within the definition of a medicinal product under the Human Medicines Regulations 2012, a peptide-containing product must hold a marketing authorisation to be legally sold or supplied in the UK

Currently, no enzyme has been shown to serve as a catalyst of S -glutathionylation in situ , although roles for human glutaredoxin-1 (GRX1

one receptor (GLP-1) , while Tirzepatide targets two (GLP-1 and GIP)

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