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*Correspondence: Yulong Yin, [email protected] Deng, [email protected] These authors have contributed equally to this work This article was submitted to Microorganisms in Vertebrate Digestive Systems, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Cells in the gut produce hormones (enteroendocrine cells) such as glucagon-like peptide (GLP-1), gastric inhibitory peptide (GIP), peptide YY, secretin, gherlin, gastrin, and many others

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Under aerobic conditions, the primary activities of PDC and OGDHC enzyme complexes become key metabolic regulatory nodes as they control: (i) for PDC, the conversion of pyruvate to acetyl-CoA, a key TCA carbon source (Fig

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