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THF is further processed into 5,10-methylene-THF , which provides a methyl group to convert homocysteine to methionine, with the help of the enzyme methionine synthase and vitamin B12

doi: 10.1016/j.bioactmat.2022.04.029

Costa et al, 2022
Specifically, increased ARMS levels have been observed in HD mouse models and patients with HD [100]

New blood vessels form to supply nutrients
