ghk-cu tolerance desensitization downregulation Frontiers ghk-cu tolerance desensitization effectiveness over

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[DOI] [PubMed] [Google Scholar] 190.Newcomer J.W., Farber N.B., Jevtovic-Todorovic V., Selke G., Melson A.K., Hershey T., Craft S., Olney J.W

One in vivo comparison of GHK versus GHK-Cu in rat experimental wounds found that GHK alone had no effect, and only the copper-bound GHK-Cu form produced a statistically significant increase in collagen accumulation evidence that the copper ion itself, not the peptide backbone alone, may be responsible for much of the collagen-stimulating activity

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Genome 13 , 493503 (2002)

In PD, neurodegeneration primarily affects the substantia nigra area of the brain, which is also where dopamine is produced