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The acylation modification gives retatrutide a half-life of approximately six days, allowing once-weekly dosing, but that long half-life also means dosing errors compound over time rather than resolving quickly

By the same time, the FDA approved the use of a equimolar combination of IGF-1 and IGFBP-3 (Mecasermin Rinfabate, iPlex), suggesting that it would be a better choice, seeming as it will require lower doses because of the augmented half-life of the molecule and buffering effect on concentration