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However, mounting evidences confirm that glucotoxicity serve as a major cause for metabolic reprogramming of immune cells and render them incapable of effector functions

The role of augmented FAO oxidation in cancer cell proliferation is a subject of debate, with different cancers responding variably to alterations in FAO levels

Moreover, Glutamine skeleton can also fuel fatty acid synthesis in cytosol by reductive carboxylation of -Ketoglutarate, exported from mitochondria, to isocitrate through the action of a cytosolic isoform of IDH (Figure 1B)

[PubMed: 1935820] 53

Phase II and phase III failures: 20132015