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Description

Below their LCST, these hydrophilic polymers exist in an expanded state due to hydrogen bonding between water molecules and the polymers

One example is the cyclic peptide CAR (CARSKNKDC), which targets angiogenic vasculature and accelerates wound closure and re-epithelialization by enhancing keratinocyte migration via syndecan-4 signaling (Maldonado et al., 2023[85])

Wang, L., et al

animal studies suggest it may support healing of gastric ulcers and damaged intestinal lining Preclinical models suggest it may help modulate inflammation, though this has not been established in controlled human trials Known risks and side effects: Because it is sold as an unregulated research chemical rather than a manufactured pharmaceutical, product purity and dosing accuracy cannot be verified, and the FDA has flagged potential impurities and manufacturing-quality concerns FDA's Category 2 determination specifically cited potential immune reactions and hypersensitivity as a safety concern User-reported (non-clinical-trial) effects include injection-site irritation, redness, or swelling, along with occasional headache, nausea, or lightheadedness, based on anecdotal reporting rather than controlled studies No long-term human safety data exists