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The study comprised a single intravenous (i.v.) administration of the peptide (20 g/kg in Sprague-Dawley rats and 6 g/kg in beagle dogs), a single intramuscular (i.m.) administration of 20, 100, or 500 g/kg (rats) and 6, 30, or 150 g/kg (dogs), and repeated i.m

Furthermore, the Hirshfeld charges of Ru sites for the Ru-hydroxide and Ru-oxide are studied, revealing that the Ru sites in Ru-hydroxide lose fewer electrons (0.542 |e|) compared to Ru-oxide, indicating a significantly higher electron density in Ru-hydroxide (Fig
doi: 10.3389/fpsyt.2019.00269

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Cell Death Dis 11(10):929 Nezu M et al (2017) Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression