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NAD is a coenzyme central to mitochondrial function, DNA repair, and sirtuin activation

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Molecular Mechanisms of Vitamin E Signaling in the Retina Vitamin E is known to activate kinases and transcription factors that regulate gene expression (Figure 1)

Because HoloTC is the most specific and most sensitive laboratory biomarker for the detection of B 12 deficiency, HoloTC should be used for screening

Pediatr Hematol Oncol (2012) 29:10918

Sudakov et al
