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doi: 10.3892/ijo.2013.2050 31 AbdallahBHassanABenoistCGoulaDBehrJPDemeneixBA

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Analysis of 48 paired GC and adjacent tissues revealed significantly higher copper levels in tumors, particularly in advanced-stage and mucinous adenocarcinomasa rare, aggressive GC subtype associated with poor prognosis

For example, prostate cancers preferably colonize in the bone, uveal melanomas typically relapse to the liver, and breast cancer of different subtypes favor distinct organs to metastasize that include bone, liver, brain, and lung [4]

In other words, thiosemicarbazones are chelating ligands that can form a 5-membered chelate ring over the sulfur atom and the azomethine nitrogen atom with transition metal ions [3, 4]

[19] investigated possible pathways underlying cardiometabolic disease by high-throughput metabolic profiling of two large, well-characterized, community-based cohorts (the Framingham Heart Study and the Malmo Diet and Cancer Study)