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Malic enzymes 1 (ME1) and 3 (ME3) generate NADPH in the cytosol and mitochondrial matrix, respectively

In contrast, GPx5, GPx7, and GPx8 are notable for incorporating Cys in place of Sec, highlighting the diversity within this family of enzymes (42, 175)

The recruitment of Drp1 is stimulated by Rho-associated coiled coil-containing protein kinase 1 (ROCK1), which has been implicated in promoting albuminuria, mesangial matrix expansion, and podocyte apoptosis in diabetic nephropathy in mice (Wang et al., 2012a)