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40 Several stimuli, such as VCAM, TGF-1 and periostin, are required to awake dormant cells, and ECM stiffness can also contribute to the escape from dormancy

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While current studies highlight promising therapeutic avenues, future research should focus on validating long-term safety and efficacy through larger cohorts, while also examining the functional stability of transplanted cells, their integration with host neural circuits, and any potential off-target or neuroimmune effects to ensure clinical translatability

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Association between gout and the development of Parkinsons disease: a systematic review and meta-analysis