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Two categories exist: localized scleroderma and systemic scleroderma [38]

Targeted drug delivery (TDD) Targeted drug delivery stands as a meticulous approach, directing medication accurately to afflicted cells or tissues, thereby amplifying their therapeutic impact while mitigating adverse effects on healthy cells or tissues [168, 169]

The raw FASTQ files were aligned to the mm39 reference genome using CellRanger v8.0.1 (10X Genomics)