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First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose

Chronic treatment should be with an oral B 12 preparation

doi: 10.1186/gb-2005-6-13-r108
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doi: 10.1158/1055-9965.EPI-20-0743 118 SouleSKingJAMillarRP
