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There was no difference in mitochondrial DNA copy number and the level of several proteins related to mitochondria in comparison to control group in 2-week-old mdx mice (45)

Addressing these limitations requires the incorporation of more physiologically relevant models, such as humanized animal models and organ-on-chip technologies, into the drug development pipeline

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J Neurosci Res 85(11):24332440 Ikeda-Matsuo Y, Tanji H, Narumiya S, Sasaki Y (2011) Inhibition of prostaglandin E2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms