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Active cancer is a relative contraindication: because GHK-Cu promotes cell growth, providers avoid it in uncontrolled malignancy (though ironically it also has anti-cancer gene effects)

The problem: You're dramatically increasing copper concentration beyond what skin can handle

It regulates over 4000 human genes, with the end result being a potential improvement in skin health which can support a more youthful look

For example, surveys and claims-data show that atorvastatin (a cholesterol-lowering statin) and amlodipine (a blood-pressure calcium-blocker) were the #1 and #2 most prescribed drugs by claims in 2025

J Annu Rev Med 57:118 Senger DR, Davis GE (2011) Angiogenesis

The agitation breaks the weak bonds holding the protein in its active shape