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There were no associations with duration of treatment, or symptom changes

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For instance, continuous increases in myelin debris cannot be accommodated by microglia in the long-term, which subsequently leads to dysfunctional lysosomal activity and a noticeable increase in insoluble lipofuscin-like granulesa marker of aging, dystrophy and possibly senescencein mice (Safaiyan et al., 2016)

Like hemoglobin and myoglobin, the cytochromes generally contain one heme group per polypeptide, except for cytochrome b which has two heme residues in one polypeptide chain

At the biochemical level, the excessive accumulation of reactive oxygen species (ROS) induced by drought leads to severe membrane lipid peroxidation, manifested by a significant increase in malondialdehyde (MDA) content, which further damages the integrity of proteins, nucleic acids, and biological membranes (Zhi et al., 2024)

An overview of the mechanisms of ERS is given in ( Figure 2 )