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Description
PMID: 40280541

Exposure to polyethylene terephthalate micro(nano)plastics exacerbates inflammation and fibrosis after myocardial infarction by reprogramming the gut and lung microbiota and metabolome

found that a substance called dehydroabietic acid binds to Keap1, activates NRF2-ARE, induces downstream gene expression, which in turn upregulates GSH, GPX4, inhibits ROS accumulation and lipid peroxidation, suppresses ferroptosis and NAFLD [148]

EDN, as its name implies, was discovered as the neurotoxin that accounted for the Gordon phenomenon, described in 1933, in which splenic extracts from patients with the Hodgkins disease caused severe damage to myelinated neurons in experimental animals.87 Distinctive hexagonal, bipyramidal crystals were initially described in 1853 in a patient with leukemia and later, in 1872, in the sputa of asthmatic patients

From the mid-forties, however, the ability to synthesise this sulphur-containing tripeptide declines

Alternative models for drug development are used less frequently
