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No published results from the one Phase II trial that was actually conducted

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Treatment with GLP-1MK-801 led to a decrease in plasma cholesterol levels compared with vehicle treatment and treatment with either GLP-1 or MK-801 (Fig

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Signal transducer and activator of transcription (STAT) 3 was silenced through the use of an siRNA targeting STAT3 (siSTAT3)

Two trials of DPP-4 inhibitors, namely, Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR)Thrombolysis in Myocardial Infarction (TIMI) 53 and Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care in Patients with Type 2 Diabetes Mellitus and Acute Coronary Syndrome (EXAMINE), showed no increased risk of major adverse cardiovascular events [7, 8]